Patients around the world come to us for the high level of specialised care we provide to treat haemotologic cancers, of which the World Health Organization estimates there are as many as 72 types and sub-types.
To help our patients battle the affliction of cancer to the blood, we draw on the collective expertise of our multidisciplinary team as well as wealth of experience gleaned from successfully treating some of the most challenging and complex cases.
Being at the forefront of medical advancements gives us the capability and confidence to provide our patients with newer treatment options. Our team of haematologists have one of the most comprehensive and cutting-edge range of treatments , from intensive chemotherapy, molecular targeted therapy and novel immunotherapy to stem cell transplantation. For each patient, we will devise a personalised treatment plan incorporating the best of these treatment modalities to create optimal clinical outcomes.
Haematopoietic Stem Cell Transplantation
Haematopoietic stem cell transplantation (or bone marrow transplantation as it is more commonly known) is a highly specialised procedure, which is effective in treating many types of cancers as well as some nonmalignant conditions. More than one million transplants have been performed around the world since the early 1950’s, and the success of the procedure is dependent on the skill and experience of the multidisciplinary transplant team.
At PCC, our transplant doctors have trained and worked in some of the leading transplant centres in the world. They have extensive experience in bone marrow transplants in both adult and paediatric patients.
We perform both autologous and allogeneic haematopoietic stem cell transplantations (including the use of related donor, unrelated donor, umbilical cord blood, or haplo-identical donor transplantation). We utilise advanced treatment protocols, which are individually tailored to each patient’s medical condition to ensure that toxicities are minimised. As part of their treatment plan, patients will have access to novel immunotherapy and chemotherapy before and after the transplant to maximise the success of their transplant.
The field of haematology covers a broad spectrum of blood disorders. We provide a comprehensive one-stop service for the diagnostic investigations and treatment of a wide range of benign blood and bone marrow disorders. This includes:
- All types of anaemia (iron deficiency anaemia, B12/ Folate deficiency, anaemia of chronic disease)
- Inherited red cell disorders (e.g. sickle cell disease, thalassemia)
- Autoimmune hemolytic anemia, an immune-mediated disease causing a low red blood cell count
- Idiopathic thrombocytopenic purpura (ITP), an immunemediated disease causing a low platelet count
- Clotting problems (deep venous thrombosis or pulmonary embolus)
- Bleeding or bruising problems (e.g. hemophilia)
- Iron metabolism disorders such as haemochromatosis (iron overload)
STEM CELL TRANSPLANTATION
What is stem cell transplantation?
Haematopoietic stem cell transplantation (or bone marrow transplantation as it is commonly termed) refers to a highly specialised procedure where stem cells are transplanted into the body for treatment of cancers and blood disorders. Over a million transplants have been performed since the procedure was accepted in the early 1950s and ongoing research continues to advance its treatment efficacy.
What are stem cells?
Stem cells are cells that have two specific and unique properties – the ability to renew by dividing themselves and creating more stem cells of their kind; and the ability to mature into specialised cells that carry out a specific function. Because haematopoietic stem cells can grow into any of the cells found in the bloodstream, they can produce the cells that the body and immune system need in order to function. This makes stem cell transplantation an exciting medical advancement.
What conditions can benefit from stem cell transplantation?
Haematopoietic stem cell transplantation has been used successfully around the world in the treatment of certain cancers as well as blood and autoimmune disorders, including:
Is stem cell transplantation safe? What is involved?
Even though stem cell transplantation has been proven to be a life-saving treatment, there are associated risks. These risks will be clearly explained to the patients and caregivers before they consent to the procedure. The process, in brief, involves three main stages.
1. Conditioning – The patient receives chemotherapy and/or radiation to kill the diseased cells and to change the immune system.
2. Infusion – Healthy stem cells are infused into the body to replace the damaged cells. This is a non-surgical procedure similar to blood transfusion.
3. Engraftment – The transplanted stem cells begin to grow and produce healthy red and white blood cells and platelets over the course of two to four weeks.
PCC Haematology and Stem Cell Transplant Centre
For patients with conditions in which stem cell transplantation is a feasible option, the state of the art PCC Haematology and Stem Cell Transplant Centre is purpose built to facilitate this treatment for optimal results. Renowned for the high standard of specialised care we provide to treat haematological cancers, PCC Haematology and Stem Cell Transplant Centre has become a highly sought-after facility by patients around the world since its inception in 2006.
Our team of transplant specialists are highly regarded in the field of haematopoietic stem cell transplantation globally. To deliver complete and coordinated care, our transplant specialists are fully supported by a dedicated patient care team including transplant-trained nurses, counsellors, dietitians and other professionals.
Patient care will be directly supervised by one of our highly accomplished transplant consultants, and every patient will also be assigned a personal transplant co-ordinator.
Each patient will receive a personalised treatment plan from our transplant specialists. Patients and their families will be closely supported by our medical and nursing team throughout the whole transplant process.
Our services include:
Autologous Haematopoietic Stem Cell Transplantation
Using bone marrow or peripheral blood stem cells from the patient
Allogeneic Haematopoietic Stem Cell Transplantation
Using stem cells from:
- Related donors
- Unrelated donors
- Umbilical cord blood
- Haplo-identical donors (usually parents of the patient)
Our patients are treated in a comfortable and comforting environment, with full access to some of the latest and most advanced medical equipment at Gleneagles Hospital, Mount Elizabeth Hospital and Mount Elizabeth Novena Hospital – including well-appointed patient suites, outpatient transplant facilities and transplant rooms fully equipped with positive pressure and HEPA filtration systems.